The 360° anti-aging revolution
for sensitive skin
Inci Name
(Active)
Solanum lycopersicum L.
(Tomato) fruit lipids
Function
(EU, PCPC)
Skin conditioning
Green
Extraction
Supercritical CO2
Is a liposoluble cosmetic active ingredient, 100% natural and organic, with soothing/anti-redness, moisturing and anti-aging clinically proven effects on sensitive skin.
Also by enhancing positive emotions, INTELLIGENE® Defense promotes the endogenous release of the hormone DHEA (dehydroepiandrosterone). This action helps improve overall well-being and restore the body’s natural balance.
Design Innovation
it is a unique wax from tomato skin, depleted in lycopene and carotene (natural colorants), easily formulated in cosmetic emulsions. This distinctive cosmetic active activates the skin's natural defence system by up-regulating antimicrobial-peptides (AMPs), helping the epidermis restore itself and enhance its protective properties in full autonomy, that results in a sooth, balanced and then a healthy skin.
Signature: Similia similibus curantur:
« Like cures like » (Paracelsus 1493-1541)
The Doctrine of Signatures, or the Doctrine of Correspondences, was developed in Europe in the 16th and 17th centuries. The theory asserts that the way plants (minerals and others) look, feel, taste, or react suggests their medicinal application.
Firstly, tomato fruit was perceived to have four chambers and be red like the human heart. Secondly, it is loaded with lycopene which is pure heart and blood food.
However, thanks to current science we know that the tomato contains much more that only lycopene as a bioactive molecule. The peel lipophilic wax, a complex matrix of natural chemical compounds that provides synergy, playing a key role in the protection of the fruit.
The Aztecs identified many therapeutic qualities in the tomato, which they used to treat certain skin disorders.
According to the Signature Theory, this observation identified the redness of tomato skin with the inflammation of the human skin (when reddened).
This is what gave us the idea to study this property. Using transcriptomics and proteomics, we have clinically proven a soothing effect by Intelligene Defense which is enhanced by a holistic approach.
Discover this philosophy
A Phylosophy based on Balance and Autonomy
The tomato's plant represents the perfect gender balance, as it contains both male and female organs within its flower. After blooming, the flower self-pollinates and generates the fruit in full autonomy.
The INTELLIGENE® Defense philosophy is based on the principles of balance and autonomy.
The human body is constantly restoring balance to achieve homeostasis. Depending on internal and external conditions, it is constantly self-regulating. Balance is not a stable and unchanging state but a perpetual movement, which seeks to compensate for the shortcomings, the attacks, the vulnerabilities of the organs in general and of the skin.
INTELLIGENE® Defense philosophy is based on a holistic approach: we believe skincare to be both a long-term prevention solution and means to activate immediate responses to the skin's specific needs at a particular unbalanced period. Thus, INTELLIGENE® Defense supports the natural defence functions of the skin allowing the epidermis to set balance itself on its own. in complete autonomy.
Based on principles of balance and autonomy, INTELLIGENE® DEFENSE activates the innate immune powers of the skin. It helps it to protect and strengthen itself by restoring its natural balance. Thus, the skin resists better in the long term or to a temporary imbalance in complete autonomy.
Biological activity
At the transcriptomic level
(on skin explant model, ex-vivo):
• Reduces the expression of genes that code to production of inflammatory cytokines and chemokines: IL6, IL8, CXCL2, CXCL8, CCL20
• Increases the expression of genes that code to production of end-stage differentiation keratinocytes: SPRR2A, SPRR2B, reinforcing the barrier function of the skin
• Stimulates the expression of key genes involved in the reinforcement of the extracellular matrix (ECM) and basement membrane (BM): COL3A1, COL21A1, HAS2, LAMA5, LAMA4
• Inhibits the expression of key genes associated with extracellular matrix degradation (SASP, Senescence-Associated Secretory Phenotype): MMP1, MMP2, MMP10, PTGS2, LIF, TNFAIP6
At the proteomic level
Skin explants model (ex-vivo):
• Increases the production of IL-10, Caspase-14, OCLN, ZO-2
• Decreases the production of TRPV1, CGRP
At the clinical level
(4 in-vivo studies carried out on 20 or 30 women, with sensitive skin condition)
• Hydration, soothing, anti-redness effect and skin barrier function reinforcement.
• Wellbeing enhancement: Attenuation of stress levels / Regulation of the HPA axis: Decreases stress levels (measured by salivary cortisol) and increases calm emotions, positive mood, and vitality (measured by increased salivary DHEA and emotional responses using SAM and BMIS).
• Recommended Dosis: from 0.5% to 1%.
Applications
Skincare for sensitive skins, Balancing skin care, Sun care, After-sun, Scalp care (coloration, sensitive scalp), well-being body, face and scalp treatments, healthy-ageing cosmetics, atopic-prone tendency skincare, dermo cosmetics, baby care.
Formulation
Incorporation
For cold and hot processes, incorporate INTELLIGENE® Defense in the oily phase at temperature higher than 30°C.
Thermostability
A temperature of up to 100°C for a very short time will not affect the stability of INTELLIGENE® Defense.
Color
Orange reddish.
In a cream formulation the colouring is from light yellow to peach-like color at recommended doses.
For more information, contact us
The 360° anti-aging revolution
for sensitive skin
Is a liposoluble cosmetic active ingredient, 100% natural and organic, with soothing/anti-redness, moisturing and anti-aging clinically proven effects on sensitive skin.
Also by enhancing positive emotions, INTELLIGENE® Defense promotes the endogenous release of the hormone DHEA (dehydroepiandrosterone). This action helps improve overall well-being and restore the body’s natural balance.
Design Innovation
it is a unique wax from tomato skin, depleted in lycopene and carotene (natural colorants), easily formulated in cosmetic emulsions. This distinctive cosmetic active activates the skin's natural defence system by up-regulating antimicrobial-peptides (AMPs), helping the epidermis restore itself and enhance its protective properties in full autonomy, that results in a sooth, balanced and then a healthy skin.
Signature: Similia similibus curantur:
« Like cures like » (Paracelsus 1493-1541)
The Doctrine of Signatures, or the Doctrine of Correspondences, was developed in Europe in the 16th and 17th centuries. The theory asserts that the way plants (minerals and others) look, feel, taste, or react suggests their medicinal application.
Firstly, tomato fruit was perceived to have four chambers and be red like the human heart. Secondly, it is loaded with lycopene which is pure heart and blood food.
However, thanks to current science we know that the tomato contains much more that only lycopene as a bioactive molecule. The peel lipophilic wax, a complex matrix of natural chemical compounds that provides synergy, playing a key role in the protection of the fruit.
The Aztecs identified many therapeutic qualities in the tomato, which they used to treat certain skin disorders.
According to the Signature Theory, this observation identified the redness of tomato skin with the inflammation of the human skin (when reddened).
This is what gave us the idea to study this property. Using transcriptomics and proteomics, we have clinically proven a soothing effect by Intelligene Defense which is enhanced by a holistic approach.
Discover this philosophy
A Phylosophy based on Balance and Autonomy
The tomato's plant represents the perfect gender balance, as it contains both male and female organs within its flower. After blooming, the flower self-pollinates and generates the fruit in full autonomy.
The INTELLIGENE® Defense philosophy is based on the principles of balance and autonomy.
The human body is constantly restoring balance to achieve homeostasis. Depending on internal and external conditions, it is constantly self-regulating. Balance is not a stable and unchanging state but a perpetual movement, which seeks to compensate for the shortcomings, the attacks, the vulnerabilities of the organs in general and of the skin.
INTELLIGENE® Defense philosophy is based on a holistic approach: we believe skincare to be both a long-term prevention solution and means to activate immediate responses to the skin's specific needs at a particular unbalanced period. Thus, INTELLIGENE® Defense supports the natural defence functions of the skin allowing the epidermis to set balance itself on its own. in complete autonomy.
Based on principles of balance and autonomy, INTELLIGENE® DEFENSE activates the innate immune powers of the skin. It helps it to protect and strengthen itself by restoring its natural balance. Thus, the skin resists better in the long term or to a temporary imbalance in complete autonomy.
Biological activity
At the transcriptomic level
(on skin explant model, ex-vivo):
• Reduces the expression of genes that code to production of inflammatory cytokines and chemokines: IL6, IL8, CXCL2, CXCL8, CCL20
• Increases the expression of genes that code to production of end-stage differentiation keratinocytes: SPRR2A, SPRR2B, reinforcing the barrier function of the skin
• Stimulates the expression of key genes involved in the reinforcement of the extracellular matrix (ECM) and basement membrane (BM): COL3A1, COL21A1, HAS2, LAMA5, LAMA4
• Inhibits the expression of key genes associated with extracellular matrix degradation (SASP, Senescence-Associated Secretory Phenotype): MMP1, MMP2, MMP10, PTGS2, LIF, TNFAIP6
At the proteomic level
Skin explants model (ex-vivo):
• Increases the production of IL-10, Caspase-14, OCLN, ZO-2
• Decreases the production of TRPV1, CGRP
At the clinical level
(4 in-vivo studies carried out on 20 or 30 women, with sensitive skin condition)
• Hydration, soothing, anti-redness effect and skin barrier function reinforcement.
• Wellbeing enhancement: Attenuation of stress levels / Regulation of the HPA axis: Decreases stress levels (measured by salivary cortisol) and increases calm emotions, positive mood, and vitality (measured by increased salivary DHEA and emotional responses using SAM and BMIS).
• Recommended Dosis: from 0.5% to 1%.
Applications
Skincare for sensitive skins, Balancing skin care, Sun care, After-sun, Scalp care (coloration, sensitive scalp), well-being body, face and scalp treatments, healthy-ageing cosmetics, atopic-prone tendency skincare, dermo cosmetics, baby care.
Formulation
Incorporation
For cold and hot processes, incorporate INTELLIGENE® Defense in the oily phase at temperature higher than 30°C.
Thermostability
A temperature of up to 100°C for a very short time will not affect the stability of INTELLIGENE® Defense.
Color
Orange reddish.
In a cream formulation the colouring is from light yellow to peach-like color at recommended doses.
For more information, contact us
